Various aspects of Baltimore life have been depicted in movies and TV:

Jewish Baltimore: Barry Levinson

http://en.wikipedia.org/wiki/Barry_Levinson

 

Weird White "Hon" Baltimore: John Waters

 http://en.wikipedia.org/wiki/John_Waters

 

Gritty Urban Baltimore: The Wire (David Simon) TV series

http://en.wikipedia.org/wiki/The_Wire

 

Roc TV series - not sure how to describe this one as it's been a long time since I watched it, but it's about a garbage collector in Baltimore-

http://en.wikipedia.org/wiki/Roc_(TV_series)

 

And I'm sure there's more that I'm leaving out. This post will be updated when I think of more!