Domain Architecture Of BRCA2-2

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beta two and another between beta four and beta five, that permits for robust ssDNA binding.[68]


The Tower domain adopts a secondary structure consisting of a try of long, parallel alpha-helices (the stem) that support a three-helix bundle (3HB) at their finish. The 3HB contains a helix-turn-helix motif and is analogous to the deoxyribonucleic acid binding domains of the microorganism site-specific recompenses, and of organism my and home domain transcription factors. The Tower domain has a very important role within the neoplasm suppressor perform of BRCA2, and is important for applicable binding of BRCA2 to deoxyribonucleic acid.[68]

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