Whereas some companies use all-natural ingredients, others use synthetic ingredients. Synthetic supplements may not provide the same benefits of natural supplements. To find out which supplements contain natural or synthetic ingredients, look at the label. If you see words that start with "dl" or end with "ide" and "ate," these supplements contain synthetics. Instead, look for vitamins that say 100 percent natural on the label or contain food items in the ingredient list. These supplements may provide the most benefit and help improve deficiencies in your diet.